Exploring Adverse Outcome Pathways for Nanomaterials with semantic web technologies

July 3, 2023

Authors: Jeaphianne van Rijn, Marvin Martens , Ammar Ammar , Mihaela-Roxana Cimpan , Valerie Fessard , Peter Hoet , Nina Jeliazkova , Sivakumar Murugadoss , Ivana Vinković Vrček , Egon Willighagen

Adverse Outcome Pathways (AOPs) have been proposed to facilitate mechanistic understanding of interactions of chemicals/materials with biological systems. Each AOP starts with a molecular initiating event (MIE) and possibly ends with adverse outcome(s) (AOs) via a series of key events (KEs). So far, the interaction of engineered nanomaterials (ENMs) with biomolecules, biomembranes, cells, and biological structures, in general, is not yet fully elucidated yet.